AC-4-130

• CAT Number: I021246
• CAS Number: 1834571-82-2
• Molecular Formula: C37H36ClF5N2O5S
• Molecular Weight: 751.20
• Purity: ≥95%
• Synonyms: 4-[[2-[(4-chlorophenyl)methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-[(3,5-ditert-butylphenyl)methyl]amino]benzoic acid
• InChI: InChI=1S/C37H36ClF5N2O5S/c1-36(2,3)24-15-22(16-25(17-24)37(4,5)6)19-45(27-13-9-23(10-14-27)35(47)48)28(46)20-44(18-21-7-11-26(38)12-8-21)51(49,50)34-32(42)30(40)29(39)31(41)33(34)43/h7-17H,18-20H2,1-6H3,(H,47,48)
• InChIKey: NMQUSJQZQWKQBL-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC(=CC(=C1)CN(C2=CC=C(C=C2)C(=O)O)C(=O)CN(CC3=CC=C(C=C3)Cl)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F)C(C)(C)C

AC-4-130（Cat No.:I021246）is a potent, selective small-molecule inhibitor targeting STAT5 (Signal Transducer and Activator of Transcription 5), a transcription factor frequently dysregulated in hematologic malignancies such as leukemia. By disrupting STAT5 phosphorylation and dimerization, AC-4-130 impairs its nuclear translocation and transcriptional activity, leading to reduced expression of oncogenic target genes. It has shown strong antiproliferative and pro-apoptotic effects in preclinical models of acute myeloid leukemia (AML) and other STAT5-driven cancers. AC-4-130 serves as a promising therapeutic candidate and a valuable tool for studying STAT5-mediated oncogenic signaling and targeted cancer therapy.