For research use only. Not for therapeutic Use.
AC-261066(CAT: I000996) is a potent, orally bioavailable, and isoform-selective retinoic acid receptor beta2 (RARβ2) agonist with a reported pEC50 of 8.0. Designed to selectively activate RARβ2 signaling, AC-261066 provides a valuable tool for investigating the role of retinoic acid pathways in cellular differentiation, gene regulation, and tissue development. Pharmacokinetic studies in rats demonstrate favorable oral bioavailability (F = 52%), supporting its potential for systemic applications in vivo. Its selectivity and efficacy make AC-261066 an important compound for research in retinoid pharmacology, neurological disease models, and therapeutic strategies targeting RARβ2-mediated signaling.
| CAS Number | 870773-76-5 |
| Synonyms | 4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]-2-fluorobenzoic acid |
| Molecular Formula | C17H20FNO4S |
| Purity | ≥95% |
| IUPAC Name | 4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]-2-fluorobenzoic acid |
| InChI | InChI=1S/C17H20FNO4S/c1-3-4-7-22-8-9-23-15-11(2)24-16(19-15)12-5-6-13(17(20)21)14(18)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,20,21) |
| InChIKey | HSAOETBFVAWNRP-UHFFFAOYSA-N |
| SMILES | CCCCOCCOC1=C(SC(=N1)C2=CC(=C(C=C2)C(=O)O)F)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
