For research use only. Not for therapeutic Use.
ABR-238901（Cat No.:I045267）is a potent, selective antagonist of S100A9, a calcium-binding protein involved in inflammation, immune cell recruitment, and tumor progression. By blocking S100A9’s interaction with pattern recognition receptors such as TLR4 and RAGE, ABR-238901 inhibits downstream pro-inflammatory signaling and reduces leukocyte infiltration. It has shown efficacy in preclinical models of sepsis, autoimmune diseases, and cancer, where S100A9-driven pathways contribute to pathology. With strong selectivity, oral bioavailability, and anti-inflammatory effects, ABR-238901 is a valuable research tool for studying S100A9 biology and developing novel therapeutic strategies targeting inflammatory and immune-mediated disorders.
| CAS Number | 1638200-22-2 |
| Synonyms | 5-bromo-N-(5-chloro-4-oxo-1H-pyridin-3-yl)-6-methoxypyridine-3-sulfonamide |
| Molecular Formula | C11H9BrClN3O4S |
| Purity | ≥95% |
| IUPAC Name | 5-bromo-N-(5-chloro-4-oxo-1H-pyridin-3-yl)-6-methoxypyridine-3-sulfonamide |
| InChI | InChI=1S/C11H9BrClN3O4S/c1-20-11-7(12)2-6(3-15-11)21(18,19)16-9-5-14-4-8(13)10(9)17/h2-5,16H,1H3,(H,14,17) |
| InChIKey | IXVPHMAWVYMOQL-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=N1)S(=O)(=O)NC2=CNC=C(C2=O)Cl)Br |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
