For research use only. Not for therapeutic Use.
ABM-14 (Cat No.: I045461) is a small-molecule inhibitor targeting the protein–protein interaction between MDM2 and p53, a key regulatory axis controlling cell cycle arrest and apoptosis. By blocking MDM2 binding, ABM-14 stabilizes and activates p53, promoting transcription of genes involved in tumor suppression. It is studied in oncology research for its potential to restore p53 function in cancers with wild-type TP53 but overexpressed MDM2. ABM-14 serves as a valuable chemical probe for investigating p53 signaling pathways and developing targeted anticancer therapeutics based on MDM2 inhibition.
| CAS Number | 1973408-76-2 |
| Synonyms | 4-[3-[4-(4-hydroxyphenyl)phenyl]-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
| Molecular Formula | C25H18F3N3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H18F3N3O2S/c1-24(2)22(33)30(19-10-5-17(14-29)21(13-19)25(26,27)28)23(34)31(24)18-8-3-15(4-9-18)16-6-11-20(32)12-7-16/h3-13,32H,1-2H3 |
| InChIKey | WVKLCXDKHAOSGV-UHFFFAOYSA-N |
| SMILES | CC1(C(=O)N(C(=S)N1C2=CC=C(C=C2)C3=CC=C(C=C3)O)C4=CC(=C(C=C4)C#N)C(F)(F)F)C |
| Reference | [1]. Meizhong Jin, et al. Compounds and methods for the targeted degradation of the androgen receptor. WO2016118666A1. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
