Abiraterone sulfate

• CAT Number: I042490
• CAS Number: 1993430-25-3
• Molecular Formula: C24H31NO4S
• Molecular Weight: 429.57
• Purity: ≥95%
• Synonyms: [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate
• InChI: InChI=1S/C24H31NO4S/c1-23-11-9-18(29-30(26,27)28)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22H,6,8-12,14H2,1-2H3,(H,26,27,28)/t18-,19-,21-,22-,23-,24+/m0/s1
• InChIKey: LUQSJWRTYLGZJB-VJLLXTKPSA-N
• SMILES: CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)OS(=O)(=O)O

Abiraterone sulfate (Cat No.: I042490) is the water-soluble salt form of abiraterone, a potent and selective inhibitor of CYP17A1—an enzyme critical for androgen biosynthesis. It is used as a prodrug of abiraterone acetate in the treatment of metastatic castration-resistant prostate cancer (mCRPC). By blocking androgen production in the testes, adrenal glands, and prostate tumor tissue, abiraterone sulfate helps suppress tumor growth. This compound is essential in hormone therapy regimens and plays a key role in advanced prostate cancer management and clinical research.

Reference

[1]. Hu Y, Huang J, et al. Simultaneous determination of abiraterone and its five metabolites in human plasma by LC-MS/MS: Application to pharmacokinetic study in healthy Chinese subjects. J Pharm Biomed Anal. 2022 Aug 5;217:114826.
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