Abemaciclib metabolite M20

• CAT Number: I017816
• CAS Number: 2138499-06-4
• Molecular Formula: C₂₇H₃₂F₂N₈O
• Molecular Weight: 522.59
• Purity: 95%
• Storage: Store at -20°C
• IUPAC Name: [6-[2-[[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]amino]-5-fluoropyrimidin-4-yl]-4-fluoro-1-propan-2-ylbenzimidazol-2-yl]methanol
• InChI: InChI=1S/C27H32F2N8O/c1-4-35-7-9-36(10-8-35)15-18-5-6-23(30-13-18)32-27-31-14-21(29)25(34-27)19-11-20(28)26-22(12-19)37(17(2)3)24(16-38)33-26/h5-6,11-14,17,38H,4,7-10,15-16H2,1-3H3,(H,30,31,32,34)
• InChIKey: KUJBDJBMXOTNIT-UHFFFAOYSA-N
• SMILES: CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)CO)F

Abemaciclib metabolite M20 (Cat No.:I017816) is a major active metabolite of abemaciclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor used for the treatment of advanced breast cancer. M20 inhibits cell growth and induces cell cycle arrest in the G1 phase in CDK4/6-dependent tumor cells, and is being investigated as a potential therapeutic agent for the treatment of breast and other types of cancer.