For research use only. Not for therapeutic Use.
Abemaciclib metabolite M18 hydrochloride(CAT:I046016) is an active metabolite of abemaciclib, a selective and orally bioavailable inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). Like the parent compound, M18 retains inhibitory activity against CDK4/6, key regulators of cell cycle progression through phosphorylation of the retinoblastoma (Rb) protein. This metabolite contributes to the pharmacological effects of abemaciclib in cancer therapy, particularly in hormone receptor-positive, HER2-negative breast cancer. Supplied as the hydrochloride salt, Abemaciclib metabolite M18 is useful as a reference standard for pharmacokinetic, bioanalytical, and metabolism studies, as well as for exploring CDK4/6 signaling pathways in oncology research.
| CAS Number | 2704316-82-3 |
| Synonyms | [4-fluoro-6-[5-fluoro-2-[[5-(piperazin-1-ylmethyl)pyridin-2-yl]amino]pyrimidin-4-yl]-1-propan-2-ylbenzimidazol-2-yl]methanol;hydrochloride |
| Molecular Formula | C25H29ClF2N8O |
| Purity | ≥95% |
| IUPAC Name | [4-fluoro-6-[5-fluoro-2-[[5-(piperazin-1-ylmethyl)pyridin-2-yl]amino]pyrimidin-4-yl]-1-propan-2-ylbenzimidazol-2-yl]methanol;hydrochloride |
| InChI | InChI=1S/C25H28F2N8O.ClH/c1-15(2)35-20-10-17(9-18(26)24(20)32-22(35)14-36)23-19(27)12-30-25(33-23)31-21-4-3-16(11-29-21)13-34-7-5-28-6-8-34;/h3-4,9-12,15,28,36H,5-8,13-14H2,1-2H3,(H,29,30,31,33);1H |
| InChIKey | WGFYSOPSZMTSSV-UHFFFAOYSA-N |
| SMILES | CC(C)N1C2=C(C(=CC(=C2)C3=NC(=NC=C3F)NC4=NC=C(C=C4)CN5CCNCC5)F)N=C1CO.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
