For research use only. Not for therapeutic Use.
ABD957（Cat No.:I045216）is a potent, selective inhibitor of monoacylglycerol lipase (MAGL), the primary enzyme responsible for hydrolyzing the endocannabinoid 2-arachidonoylglycerol (2-AG) into arachidonic acid. By blocking MAGL activity, ABD957 elevates 2-AG levels, enhancing cannabinoid receptor signaling and modulating pain perception, inflammation, and neuroprotection. It demonstrates high selectivity, minimizing off-target effects on related enzymes in lipid metabolism. ABD957 is a valuable research tool for studying the endocannabinoid system, lipid signaling, and cannabinoid-mediated physiological processes, with therapeutic potential in pain management, neurodegenerative diseases, and inflammatory disorders driven by dysregulated endocannabinoid turnover.
| CAS Number | 3007772-60-0 |
| Synonyms | 2-[8-[2-[[(3S)-4-[3-(dimethylsulfamoyl)pyrazole-1-carbonyl]-3-methylpiperazin-1-yl]methyl]-5-(trifluoromethyl)phenyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]acetic acid |
| Molecular Formula | C27H36F3N7O5S |
| Purity | ≥95% |
| IUPAC Name | 2-[8-[2-[[(3S)-4-[3-(dimethylsulfamoyl)pyrazole-1-carbonyl]-3-methylpiperazin-1-yl]methyl]-5-(trifluoromethyl)phenyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]acetic acid |
| InChI | InChI=1S/C27H36F3N7O5S/c1-18-13-33(10-11-35(18)26(40)36-9-8-24(31-36)43(41,42)32(2)3)14-19-4-5-20(27(28,29)30)12-23(19)37-21-6-7-22(37)16-34(15-21)17-25(38)39/h4-5,8-9,12,18,21-22H,6-7,10-11,13-17H2,1-3H3,(H,38,39)/t18-,21?,22?/m0/s1 |
| InChIKey | ISNXAOFEMNFJCO-XTWGIRIWSA-N |
| SMILES | C[C@H]1CN(CCN1C(=O)N2C=CC(=N2)S(=O)(=O)N(C)C)CC3=C(C=C(C=C3)C(F)(F)F)N4C5CCC4CN(C5)CC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
