ABC99

• CAT Number: I021198
• CAS Number: 2331255-53-7
• Molecular Formula: C22H21ClN4O5
• Molecular Weight: 456.88
• Purity: ≥95%
• Synonyms: [7-[(4-chlorophenyl)methyl]-1,3-dioxo-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl] 2,3-dihydro-1,4-benzoxazine-4-carboxylate
• InChI: InChI=1S/C22H21ClN4O5/c23-16-7-5-15(6-8-16)13-24-9-10-25-18(14-24)20(28)27(21(25)29)32-22(30)26-11-12-31-19-4-2-1-3-17(19)26/h1-8,18H,9-14H2
• InChIKey: OZPZCETZTBBQBO-UHFFFAOYSA-N
• SMILES: C1CN2C(CN1CC3=CC=C(C=C3)Cl)C(=O)N(C2=O)OC(=O)N4CCOC5=CC=CC=C54

ABC99 (Cat No.: I021198) is a selective, activity-based probe targeting fatty acid amide hydrolase (FAAH), an enzyme responsible for degrading endocannabinoids such as anandamide. By covalently binding to FAAH, ABC99 enables sensitive detection, imaging, and profiling of enzyme activity in living cells and tissues. Researchers employ ABC99 to investigate endocannabinoid signaling, neuroinflammation, pain regulation, and metabolic processes. Its high specificity and utility as a chemical probe make it a powerful tool for studying lipid signaling pathways and therapeutic strategies in neuroscience and immunology.

Reference

[1]. Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9(6):563-568.
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