For research use only. Not for therapeutic Use.
ABBV-167（Cat No.:I045214）is a potent, selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), a renal transporter responsible for reabsorbing glucose from the proximal tubule. By blocking SGLT2 activity, ABBV-167 promotes urinary glucose excretion, thereby lowering blood glucose levels and improving glycemic control. It is a valuable research tool for studying renal glucose handling, diabetes pathophysiology, and metabolic regulation. ABBV-167 holds therapeutic potential for treating type 2 diabetes, obesity, and metabolic syndrome, with possible benefits in cardiovascular and renal protection through mechanisms beyond glucose lowering.
| CAS Number | 1351456-78-4 |
| Synonyms | [5-[5-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-2-[[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonylcarbamoyl]phenoxy]pyrrolo[2,3-b]pyridin-7-yl]methyl dihydrogen phosphate |
| Molecular Formula | C46H53ClN7O11PS |
| Purity | ≥95% |
| IUPAC Name | [5-[5-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-2-[[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonylcarbamoyl]phenoxy]pyrrolo[2,3-b]pyridin-7-yl]methyl dihydrogen phosphate |
| InChI | InChI=1S/C46H53ClN7O11PS/c1-46(2)15-11-34(40(26-46)32-3-5-35(47)6-4-32)28-51-17-19-52(20-18-51)36-7-9-39(43(24-36)65-37-23-33-12-16-48-44(33)53(29-37)30-64-66(58,59)60)45(55)50-67(61,62)38-8-10-41(42(25-38)54(56)57)49-27-31-13-21-63-22-14-31/h3-10,12,16,23-25,29,31,49H,11,13-15,17-22,26-28,30H2,1-2H3,(H,50,55)(H2,58,59,60) |
| InChIKey | CLQLTQZFOGFNCT-UHFFFAOYSA-N |
| SMILES | CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN(C8=NC=CC8=C7)COP(=O)(O)O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
