Abanoquil

• CAT Number: I021188
• CAS Number: 90402-40-7
• Molecular Formula: C22H25N3O4
• Molecular Weight: 395.45
• Purity: ≥95%
• Synonyms: 2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxyquinolin-4-amine
• InChI: InChI=1S/C22H25N3O4/c1-26-18-7-13-5-6-25(12-14(13)8-19(18)27-2)22-10-16(23)15-9-20(28-3)21(29-4)11-17(15)24-22/h7-11H,5-6,12H2,1-4H3,(H2,23,24)
• InChIKey: ANZIISNSHPKVRV-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2CN(CCC2=C1)C3=NC4=CC(=C(C=C4C(=C3)N)OC)OC)OC

Abanoquil (Cat No.: I021188) is a pharmacological agent primarily investigated as a vasodilator and antihypertensive compound. It functions by blocking alpha-adrenergic receptors, which leads to the relaxation of vascular smooth muscles and a reduction in blood pressure. Abanoquil has been studied for its potential therapeutic benefits in treating hypertension and related cardiovascular conditions. Although not widely used clinically, it remains of interest in cardiovascular research for exploring mechanisms of vascular tone regulation and the development of novel antihypertensive therapies targeting adrenergic pathways.

Reference

[1]. A Giraldi, et al. Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue. Int J Impot Res. 2000 Mar;12(S1):S37-S40.
[Content Brief]

[2]. T C Tham, et al. Dose-dependent alpha 1-adrenoceptor antagonist activity of the anti-arrhythmic drug, abanoquil (UK-52,046), without reduction in blood pressure in man. Br J Clin Pharmacol. 1992 Apr;33(4):405-9.
[Content Brief]