AAT-008

For research use only. Not for therapeutic Use.

  • CAT Number: R067023
  • CAS Number: 847727-81-5
  • Molecular Formula: C21H16ClFN2O4
  • Molecular Weight: 414.81
  • Purity: ≥95%
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AAT-008(Cat No.:R067023)is a selective antagonist of the prostaglandin E2 receptor subtype EP4, which plays a key role in modulating immune responses, inflammation, and tumor progression. By blocking EP4 signaling, AAT-008 enhances antitumor immunity and inhibits immunosuppressive pathways within the tumor microenvironment. It is being investigated for use in cancer immunotherapy, particularly in combination with immune checkpoint inhibitors like anti-PD-1 antibodies. AAT-008 has shown promise in preclinical models by promoting cytotoxic T-cell activity and reducing tumor growth, making it a potential candidate for novel cancer treatment strategies.


CAS Number 847727-81-5
Synonyms

4-[(1S)-1-[[5-chloro-2-(3-fluorophenoxy)pyridine-3-carbonyl]amino]ethyl]benzoic acid

Molecular Formula C21H16ClFN2O4
Purity ≥95%
IUPAC Name 4-[(1S)-1-[[5-chloro-2-(3-fluorophenoxy)pyridine-3-carbonyl]amino]ethyl]benzoic acid
InChI InChI=1S/C21H16ClFN2O4/c1-12(13-5-7-14(8-6-13)21(27)28)25-19(26)18-9-15(22)11-24-20(18)29-17-4-2-3-16(23)10-17/h2-12H,1H3,(H,25,26)(H,27,28)/t12-/m0/s1
InChIKey FKXDPPYCCKCVCW-LBPRGKRZSA-N
SMILES C[C@@H](C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(N=CC(=C2)Cl)OC3=CC(=CC=C3)F
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