A6770（Cat No.:I021121）is a potent and selective inhibitor of G9a and GLP, two histone methyltransferases involved in epigenetic gene regulation through H3K9 dimethylation. By blocking G9a/GLP activity, A6770 reduces H3K9me2 levels, leading to chromatin remodeling and reactivation of silenced genes, including tumor suppressors. It is commonly used in cancer and neurobiology research to explore the role of epigenetic silencing in disease progression. A6770 offers a valuable chemical tool for dissecting histone methylation-dependent pathways and investigating therapeutic strategies targeting epigenetic modifications in oncology and other disorders.