For research use only. Not for therapeutic Use.
A3373(CAT: I040291) is a novel small-molecule inhibitor of phospholipase D isoforms, selectively targeting PLD1 with an IC₅₀ of 325 nM and PLD2 with an IC₅₀ of 15.15 μM. By inhibiting PLD1 activity, A3373 effectively suppresses lipopolysaccharide (LPS)-induced immune responses, making it a valuable tool for studying inflammation and immune modulation. It has demonstrated therapeutic potential in models of autoimmune arthritis, bone demineralization, and osteoclastogenesis, where PLD1 activity contributes to disease progression. A3373 is ideal for dissecting PLD-mediated signaling pathways in immune and bone-related diseases.
| CAS Number | 2324948-66-3 |
| Synonyms | N-[3,5-bis(trifluoromethyl)phenyl]-5-(hydrazinecarbonyl)-1H-indole-2-carboxamide |
| Molecular Formula | C17H9F7N2O |
| Purity | ≥95% |
| IUPAC Name | N-[3,5-bis(trifluoromethyl)phenyl]-5-(hydrazinecarbonyl)-1H-indole-2-carboxamide |
| InChI | InChI=1S/C18H12F6N4O2/c19-17(20,21)10-5-11(18(22,23)24)7-12(6-10)26-16(30)14-4-9-3-8(15(29)28-25)1-2-13(9)27-14/h1-7,27H,25H2,(H,26,30)(H,28,29) |
| InChIKey | PMWWUFQRANSVCI-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C1C(=O)NN)C=C(N2)C(=O)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
