For research use only. Not for therapeutic Use.
A3334 (Cat No.: I045457) is a potent, selective inhibitor of protein arginine methyltransferase 6 (PRMT6), an enzyme that catalyzes asymmetric dimethylation of arginine residues on histones and other proteins, influencing gene expression and cellular processes. By blocking PRMT6 activity, A3334 modulates epigenetic regulation, impacting transcription, DNA repair, and cell proliferation. It is used in chemical biology and cancer research to study PRMT6 function and its role in oncogenesis, serving as a valuable chemical probe for developing targeted epigenetic therapies and exploring PRMT6-associated disease mechanisms.
| CAS Number | 854171-31-6 |
| Synonyms | 5-methoxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol |
| Molecular Formula | C17H13N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H13N3O3/c1-23-9-6-7-13-11(8-9)14(17(21)19-13)16-15(20-22)10-4-2-3-5-12(10)18-16/h2-8,18-19,21H,1H3 |
| InChIKey | NNFVURTYXFYQFZ-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)NC(=C2C3=C(C4=CC=CC=C4N3)N=O)O |
| Reference | [1]. Choi KY, et, al. Compositions and methods for suppressing and/or treating metabolic diseases and/or a clinical condition thereof. WO2020079569. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
