A2B receptor antagonist 2

• CAT Number: I044421
• CAS Number: 784-90-7
• Molecular Formula: C12H15N5
• Molecular Weight: 229.28
• Purity: ≥95%
• Synonyms: 2-(4,6,7-trimethylquinazolin-2-yl)guanidine
• InChI: InChI=1S/C12H15N5/c1-6-4-9-8(3)15-12(17-11(13)14)16-10(9)5-7(6)2/h4-5H,1-3H3,(H4,13,14,15,16,17)
• InChIKey: JFQDHSRWWLJCBV-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(N=C(N=C2C=C1C)N=C(N)N)C

A2B receptor antagonist 2（Cat No.:I044421）is a selective inhibitor of the adenosine A2B receptor, a G protein-coupled receptor involved in inflammatory and tumorigenic signaling pathways. By blocking A2B receptor activation, this compound suppresses adenosine-induced cAMP accumulation and downstream pro-inflammatory cytokine production, including IL-6 and IL-8. It is valuable in research on cancer, fibrosis, and inflammatory diseases, where elevated extracellular adenosine levels contribute to disease progression. A2B receptor antagonist 2 aids in dissecting adenosine signaling roles in immune modulation, hypoxia response, and tumor microenvironment remodeling, supporting therapeutic exploration in immune-related conditions.