A-317567

• CAT Number: I000209
• CAS Number: 371217-32-2
• Molecular Formula: C27H31N3
• Molecular Weight: 397.56
• Purity: ≥95%
• Synonyms: 6-[2-(2-methyl-1-propan-2-yl-3,4-dihydro-1H-isoquinolin-7-yl)cyclopropyl]naphthalene-2-carboximidamide
• InChI: InChI=1S/C27H31N3/c1-16(2)26-25-14-21(7-4-17(25)10-11-30(26)3)24-15-23(24)20-8-5-19-13-22(27(28)29)9-6-18(19)12-20/h4-9,12-14,16,23-24,26H,10-11,15H2,1-3H3,(H3,28,29)
• InChIKey: FEPIUXBUJVISNN-UHFFFAOYSA-N
• SMILES: CC(C)C1C2=C(CCN1C)C=CC(=C2)C3CC3C4=CC5=C(C=C4)C=C(C=C5)C(=N)N

A-317567(CAT: I000209) is a potent acid-sensing ion channel 3 (ASIC3) inhibitor with an IC₅₀ of 1.025 μM, demonstrating both antinociceptive and antidepressant effects. In dorsal root ganglion (DRG) neurons, it concentration-dependently inhibits pH 4.5–evoked ASIC currents (IC₅₀ = 2–30 μM) and blocks the sustained phase of ASIC3-like currents, which are predominant in sensory neurons. In vivo, intraperitoneal administration (1–100 μmol/kg) provides full analgesic effects in the CFA pain model (ED₅₀ = 17 μmol/kg) without affecting contralateral paw responses. By modulating proton-gated ion channels, A-317567 is a valuable tool for studying pain mechanisms, sensory neuron signaling, and mood regulation.