A-196 - CAS 1982372-88-2

A-196(cas 1982372-88-2) is a selective inhibitor of SUV420H1 and SUV420H2 (IC50s = 25 and 144 nM, respectively) that is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. A-196 has been shown to inhibit the di- and tri-methylation of lysine 20 of histone H4 (H4K20me) in multiple cell lines with IC50 values less than 1 μM. 

Catalog Number: R065702

CAS Number: 1982372-88-2

Molecular Formula: C18H16Cl2N4

Molecular Weight:359.3

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine

Property

Molecular Formula: C18H16Cl2N4
Molecular Weight359.3
Purity≥95%
Storage-20°C

Computed Descriptor

IUPAC Name6,7-dichloro-N-cyclopentyl-4-pyridin-4-ylphthalazin-1-amine
InChIInChI=1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)
InChIKeyABGOSOMRWSYAOB-UHFFFAOYSA-N
SMILESClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1