9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

• CAT Number: R006126
• CAS Number: 981-34-0
• Molecular Formula: C₂₂H₂₈O₅
• Molecular Weight: 372.45
• Purity: ≥95%
• Synonyms: (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione;?Betamethasone 9-11-Epoxide; USP Betamethasone Related Compound E
• Storage: 2°C to 8°C
• IUPAC Name: (1S,2S,10S,11S,13S,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one
• InChI: InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)22(15)18(27-22)10-20(16,3)21(12,26)17(25)11-23/h6-7,9,12,15-16,18,23,26H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,18-,19-,20-,21-,22+/m0/s1
• InChIKey: GBDXNHBVYAMODG-DEGNENOVSA-N
• SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]35[C@@H](O5)C[C@@]2([C@]1(C(=O)CO)O)C)C

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione（Cat No.:R006126）is a synthetic corticosteroid derivative with potent anti-inflammatory properties. Structurally, it features an epoxy bridge between the 9β and 11β positions, enhancing metabolic stability and receptor selectivity. It also includes hydroxyl groups at the 17 and 21 positions, critical for glucocorticoid receptor binding and activity. The 16β-methyl substitution improves its topical efficacy and reduces systemic side effects. This compound serves as a core structure in the synthesis of several glucocorticoid drugs used to manage autoimmune, allergic, and inflammatory disorders through modulation of gene expression and immune responses.