9α-Fluoro-6α-methylprednisolone

• CAT Number: R031901
• CAS Number: 382-52-5
• Molecular Formula: C22H29FO5
• Molecular Weight: 392.47
• Purity: ≥95%
• Synonyms: 6α-Methyl-9α-fluoroprednisolone; 9α-Fluoro-11β,17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione; NSC 19621; NSC 48986
• Storage: Store at RT
• IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C22H29FO5/c1-12-8-16-14-5-7-21(28,18(27)11-24)20(14,3)10-17(26)22(16,23)19(2)6-4-13(25)9-15(12)19/h4,6,9,12,14,16-17,24,26,28H,5,7-8,10-11H2,1-3H3/t12-,14-,16-,17-,19-,20-,21-,22-/m0/s1
• InChIKey: AWFOJLJWZNBTBX-MJWISQFFSA-N
• SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)CO)O

9α-Fluoro-6α-methylprednisolone（Cat No.:R031901）is a synthetic corticosteroid derivative, structurally modified from prednisolone. The introduction of a fluorine atom at the 9α position and a methyl group at the 6α position enhances its anti-inflammatory and glucocorticoid activity while reducing mineralocorticoid effects. These modifications improve its potency and reduce the risk of water retention and electrolyte imbalances, making it effective for treating conditions like asthma, rheumatoid arthritis, and allergic reactions. As a potent anti-inflammatory agent, it also minimizes adverse side effects compared to conventional corticosteroids, making it useful in both clinical and pharmaceutical applications.