For research use only. Not for therapeutic Use.
8-M-PDOT (CAT: M112976) is a selective melatonin MT₂ receptor agonist with 5.2-fold preference for MT₂ over MT₁ receptors. It binds human recombinant MT₂ receptors with high affinity (pKi = 8.95) compared to MT₁ (pKi = 8.23). Preclinical studies demonstrate its anxiolytic-like effects, highlighting its role in modulating melatonergic signaling pathways. In vivo, direct administration into the dorsal striatum of rats produces significant anxiolytic-like activity, supporting its potential relevance in mood and circadian rhythm research. As a potent and selective probe, 8-M-PDOT is a valuable tool for investigating MT₂ receptor function in neurobiology, chronobiology, and anxiety-related disorders.
| CAS Number | 134865-70-6 |
| Synonyms | N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide |
| Molecular Formula | C14H19NO2 |
| Purity | ≥95% |
| IUPAC Name | N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide |
| InChI | InChI=1S/C14H19NO2/c1-3-14(16)15-11-8-7-10-5-4-6-13(17-2)12(10)9-11/h4-6,11H,3,7-9H2,1-2H3,(H,15,16) |
| InChIKey | RVIGBTUDFAGRTQ-UHFFFAOYSA-N |
| SMILES | CCC(=O)NC1CCC2=C(C1)C(=CC=C2)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
