8-Isoprostaglandin E2

• CAT Number: R064772
• CAS Number: 27415-25-4
• Molecular Formula: C20H32O5
• Molecular Weight: 352.47
• Purity: ≥95%
• Synonyms: (Z)-7-[(1S,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
• InChI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17+,19+/m0/s1
• InChIKey: XEYBRNLFEZDVAW-CLQOMRTCSA-N
• SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@H]1C/C=C\CCCC(=O)O)O)O

8-Isoprostaglandin E2 (Cat No.:R064772) is a biologically active isoprostane, structurally similar to prostaglandin E2 (PGE2), and is formed via non-enzymatic oxidation of arachidonic acid through free radical-induced lipid peroxidation. It serves as a key biomarker of oxidative stress and has been implicated in inflammatory responses, vasoregulation, and renal function. 8-iso-PGE2 can activate prostaglandin receptors, influencing smooth muscle tone and cell signaling pathways. It is widely used in oxidative biology, cardiovascular research, and disease models of inflammation, ischemia, and neurodegeneration, where oxidative injury plays a significant pathological role.