8-Bromo-AMP

• CAT Number: I045345
• CAS Number: 23567-96-6
• Molecular Formula: C10H13BrN5O7P
• Molecular Weight: 426.12
• Purity: ≥95%
• Synonyms: [(2R,3S,4R,5R)-5-(6-amino-8-bromopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• InChI: InChI=1S/C10H13BrN5O7P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,13,14)(H2,19,20,21)/t3-,5-,6-,9-/m1/s1
• InChIKey: DNPIJKNXFSPNNY-UUOKFMHZSA-N
• SMILES: C1=NC(=C2C(=N1)N(C(=N2)Br)C3C(C(C(O3)COP(=O)(O)O)O)O)N

8-Bromo-AMP (Cat No.: I045345) is a synthetic analog of adenosine monophosphate (AMP), modified with a bromine atom at the 8-position of the adenine ring. This modification enhances its resistance to enzymatic degradation and allows it to act as a potent activator of AMP-dependent signaling pathways, particularly protein kinase A (PKA). Commonly used in biochemical and pharmacological research, 8-Bromo-AMP helps investigate cellular processes involving cyclic nucleotides, such as metabolism, gene expression, and signal transduction in various disease and physiological models.

Reference

[1]. Jiang J, et, al. Evidences for involvement of endogenous cAMP in Arabidopsis defense responses to Verticillium toxins. Cell Res. 2005 Aug;15(8):585-92.
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[2]. Nakai T, et, al. Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. J Cardiovasc Pharmacol. 1996 Aug;28(2):264-70.
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