For research use only. Not for therapeutic Use.
8-Azido-ATP (8-N₃-ATP) trisodium(CAT: I040223) is a photoreactive nucleotide analog of ATP featuring an azide group at the 8-position, enabling both protein labeling and chemical conjugation. Commonly used for identifying nucleotide-binding proteins such as DNA-dependent RNA polymerase, it is also a versatile click chemistry reagent. The azide moiety allows for Cu-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-functionalized molecules and strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups, facilitating bioconjugation under mild conditions. Ideal for photo-crosslinking, affinity labeling, and nucleotide–protein interaction studies, this reagent supports advanced applications in chemical biology and proteomics.
| Synonyms | trisodium;[[[(2R,4S,5R)-5-(6-amino-8-azidopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate |
| Molecular Formula | C10H12N8Na3O13P3 |
| Purity | ≥95% |
| IUPAC Name | trisodium;[[[(2R,4S,5R)-5-(6-amino-8-azidopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate |
| InChI | InChI=1S/C10H15N8O13P3.3Na/c11-7-4-8(14-2-13-7)18(10(15-4)16-17-12)9-6(20)5(19)3(29-9)1-28-33(24,25)31-34(26,27)30-32(21,22)23;;;/h2-3,5-6,9,19-20H,1H2,(H,24,25)(H,26,27)(H2,11,13,14)(H2,21,22,23);;;/q;3*+1/p-3/t3-,5?,6+,9-;;;/m1.../s1 |
| InChIKey | IPQLOBGZIWMBCQ-WSNIFWRSSA-K |
| SMILES | C1=NC(=C2C(=N1)N(C(=N2)N=[N+]=[N-])C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O)O)N.[Na+].[Na+].[Na+] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
