For research use only. Not for therapeutic Use.
8-Azanebularine（Cat No.:I045132）is a synthetic nucleoside analog and cytidine deaminase inhibitor structurally related to cytidine and uridine. It mimics the transition state of the deamination reaction, thereby competitively inhibiting cytidine deaminase, an enzyme involved in pyrimidine metabolism and chemotherapeutic drug resistance. By blocking this enzyme, 8-Azanebularine enhances the efficacy of cytidine-based anticancer agents such as cytarabine and gemcitabine. It is valuable in studying RNA editing, nucleoside metabolism, and enzyme inhibition mechanisms. Supplied for biochemical research in nucleic acid chemistry, cancer therapeutics, and metabolic pathway modulation.
| CAS Number | 38874-46-3 |
| Synonyms | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(triazolo[4,5-d]pyrimidin-3-yl)oxolane-3,4-diol |
| Molecular Formula | C9H11N5O4 |
| Purity | ≥95% |
| IUPAC Name | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(triazolo[4,5-d]pyrimidin-3-yl)oxolane-3,4-diol |
| InChI | InChI=1S/C9H11N5O4/c15-2-5-6(16)7(17)9(18-5)14-8-4(12-13-14)1-10-3-11-8/h1,3,5-7,9,15-17H,2H2/t5-,6-,7-,9-/m1/s1 |
| InChIKey | XOUCEKYAMMLQRC-JXOAFFINSA-N |
| SMILES | C1=C2C(=NC=N1)N(N=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
