7-(trifluoromethyl)-1H-indole-2-carboxylic Acid

• CAT Number: L042116
• CAS Number: 172216-98-7
• Molecular Formula: C10H6F3NO2
• Molecular Weight: 229.15
• Purity: ≥95%
• IUPAC Name: 7-(trifluoromethyl)-1H-indole-2-carboxylic acid
• InChI: InChI=1S/C10H6F3NO2/c11-10(12,13)6-3-1-2-5-4-7(9(15)16)14-8(5)6/h1-4,14H,(H,15,16)
• InChIKey: PISPPXUYIZNQMU-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C1)C(F)(F)F)NC(=C2)C(=O)O

7-(Trifluoromethyl)-1H-indole-2-carboxylic acid(CAT: L042116) is a fluorinated indole derivative featuring a trifluoromethyl group at the 7-position and a carboxylic acid at the 2-position of the indole ring. This compound is valuable in medicinal chemistry and drug discovery for its role as a building block in the synthesis of bioactive molecules. The trifluoromethyl group enhances lipophilicity, metabolic stability, and binding affinity, while the carboxyl group allows for diverse functionalization. It is commonly used in the design of kinase inhibitors, GPCR ligands, and anti-inflammatory agents. Its well-defined substitution pattern supports structure–activity relationship (SAR) exploration and lead optimization.