For research use only. Not for therapeutic Use.
7-TFA-ap-7-Deaza-dG（Cat No.:I044612）is a modified nucleotide analog based on 7-deaza-2′-deoxyguanosine, where the nitrogen at position 7 of the guanine ring is replaced with a carbon. This substitution disrupts normal Hoogsteen base pairing, enhancing stability and reducing unwanted interactions in oligonucleotide synthesis. The 7-trifluoroacetyl (7-TFA) group and ap linker serve as protective and functional elements, enabling precise incorporation during automated synthesis. Widely used in molecular biology and epigenetics research, this analog aids in probing DNA structure, studying protein-DNA interactions, and developing nucleic acid-based diagnostics or therapeutic platforms.
| CAS Number | 666847-77-4 |
| Synonyms | N-[3-[2-amino-7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl]prop-2-ynyl]-2,2,2-trifluoroacetamide |
| Molecular Formula | C16H16F3N5O5 |
| Purity | ≥95% |
| IUPAC Name | N-[3-[2-amino-7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl]prop-2-ynyl]-2,2,2-trifluoroacetamide |
| InChI | InChI=1S/C16H16F3N5O5/c17-16(18,19)14(28)21-3-1-2-7-5-24(10-4-8(26)9(6-25)29-10)12-11(7)13(27)23-15(20)22-12/h5,8-10,25-26H,3-4,6H2,(H,21,28)(H3,20,22,23,27)/t8-,9+,10+/m0/s1 |
| InChIKey | RDNQXASRTWMHCY-IVZWLZJFSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=C(C3=C2N=C(NC3=O)N)C#CCNC(=O)C(F)(F)F)CO)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
