7-O-(Amino-PEG4)-paclitaxel

• CAT Number: I045966
• Molecular Formula: C58H72N2O19
• Molecular Weight: 1101.19
• Purity: ≥95%
• Synonyms: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-9-[3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoyloxy]-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
• InChI: InChI=1S/C58H72N2O19/c1-35-41(76-54(68)47(64)46(38-16-10-7-11-17-38)60-52(66)39-18-12-8-13-19-39)33-58(69)51(78-53(67)40-20-14-9-15-21-40)49-56(6,50(65)48(75-36(2)61)45(35)55(58,4)5)42(32-43-57(49,34-74-43)79-37(3)62)77-44(63)22-24-70-26-28-72-30-31-73-29-27-71-25-23-59/h7-21,41-43,46-49,51,64,69H,22-34,59H2,1-6H3,(H,60,66)/t41-,42-,43+,46-,47+,48+,49-,51-,56+,57-,58+/m0/s1
• InChIKey: VDNLACHAGAYEKT-HTFIVVNNSA-N
• SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC(=O)CCOCCOCCOCCOCCN)C)OC(=O)C

7-O-(Amino-PEG4)-paclitaxel(CAT: I045966) is a functionalized derivative of paclitaxel featuring a four-unit polyethylene glycol (PEG4) spacer terminated with a primary amine at the 7-O position. The PEG4 chain improves solubility and provides flexibility, while the amine group offers a reactive handle for covalent attachment to linkers, carriers, or imaging agents. This modification enables the development of paclitaxel-based drug conjugates, targeted delivery systems, and advanced biomedical materials. Researchers employ 7-O-(Amino-PEG4)-paclitaxel in cancer drug design, nanoparticle formulation, and bioconjugation studies, where controlled conjugation enhances therapeutic index and facilitates mechanistic investigations of microtubule-stabilizing anticancer agents.