7-Hydroxyaristolochic acid A

For research use only. Not for therapeutic Use.

  • CAT Number: I044958
  • CAS Number: 79185-75-4
  • Molecular Formula: C17H11NO8
  • Molecular Weight: 357.27
  • Purity: ≥95%
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7-Hydroxyaristolochic acid A(Cat No.:I044958)is a hydroxylated derivative of aristolochic acid A, a nitrophenanthrene carboxylic acid naturally found in Aristolochia and Asarum species. It is known for its potent nephrotoxic and carcinogenic properties, primarily due to its ability to form DNA adducts that lead to mutations. The addition of a hydroxyl group at the 7-position may influence its bioactivity and metabolic profile. Like its parent compound, 7-hydroxyaristolochic acid A is associated with aristolochic acid nephropathy and urothelial cancers, making it a subject of toxicological concern and molecular studies on chemical-induced DNA damage.


CAS Number 79185-75-4
Synonyms

9-hydroxy-8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid

Molecular Formula C17H11NO8
Purity ≥95%
IUPAC Name 9-hydroxy-8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
InChI InChI=1S/C17H11NO8/c1-24-15-8-4-10(18(22)23)13-9(17(20)21)5-12-16(26-6-25-12)14(13)7(8)2-3-11(15)19/h2-5,19H,6H2,1H3,(H,20,21)
InChIKey UCLGCTLOEZZSLA-UHFFFAOYSA-N
SMILES COC1=C(C=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O)O
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