7-Chloro-6-nitroquinazolin-4(3H)-one

• CAT Number: L012410
• CAS Number: 53449-14-2
• Molecular Formula: C8H4ClN3O3
• Molecular Weight: 225.59
• Purity: ≥95%
• IUPAC Name: 7-chloro-6-nitro-3H-quinazolin-4-one
• InChI: InChI=1S/C8H4ClN3O3/c9-5-2-6-4(1-7(5)12(14)15)8(13)11-3-10-6/h1-3H,(H,10,11,13)
• InChIKey: URDYTQYZXZKBQT-UHFFFAOYSA-N
• SMILES: C1=C2C(=CC(=C1[N+](=O)[O-])Cl)N=CNC2=O

7-Chloro-6-nitroquinazolin-4(3H)-one(CAT: L012410) is a substituted quinazolinone derivative featuring electron-withdrawing chloro and nitro groups at the 7 and 6 positions, respectively. This compound serves as a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and heterocyclic compounds, particularly those targeting kinase inhibition, anticancer activity, and antimicrobial properties. The quinazolinone core is a privileged scaffold in medicinal chemistry, offering hydrogen bonding capacity and metabolic stability. The nitro group enhances the compound’s electrophilicity, facilitating further synthetic transformations such as nucleophilic aromatic substitution.