For research use only. Not for therapeutic Use.
7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA(CAT: I040333) is a potent cytotoxic agent derived from the camptothecin class, featuring a fluorinated and methylated camptothecin scaffold with an aminomethyl substituent at the 7-position. Supplied as a trifluoroacetate (TFA) salt for enhanced solubility and stability, this compound serves as a critical intermediate in the synthesis of antibody-drug conjugates (ADCs), particularly the MC-AAA-NHCH₂OCH₂COO-linked camptothecin derivative (HY-132158). It functions by targeting topoisomerase I, disrupting DNA replication and inducing apoptosis in proliferating cancer cells. Ideal for cancer research and ADC development.
| Synonyms | (19S)-10-(aminomethyl)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;2,2,2-trifluoroacetic acid |
| Molecular Formula | C24H21F4N3O6 |
| Purity | ≥95% |
| IUPAC Name | (19S)-10-(aminomethyl)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C22H20FN3O4.C2HF3O2/c1-3-22(29)15-5-18-19-13(8-26(18)20(27)14(15)9-30-21(22)28)12(7-24)11-4-10(2)16(23)6-17(11)25-19;3-2(4,5)1(6)7/h4-6,29H,3,7-9,24H2,1-2H3;(H,6,7)/t22-;/m0./s1 |
| InChIKey | OWUWBPSWDMGYAL-FTBISJDPSA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=C(C=C(C(=C5)C)F)N=C4C3=C2)CN)O.C(=O)(C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
