7-Aminomethyl-10-methyl-11-fluoro camptothecin

• CAT Number: I045403
• CAS Number: 2378616-23-8
• Molecular Formula: C22H20FN3O4
• Molecular Weight: 409.41
• Purity: ≥95%
• Synonyms: (19S)-10-(aminomethyl)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
• InChI: InChI=1S/C22H20FN3O4/c1-3-22(29)15-5-18-19-13(8-26(18)20(27)14(15)9-30-21(22)28)12(7-24)11-4-10(2)16(23)6-17(11)25-19/h4-6,29H,3,7-9,24H2,1-2H3/t22-/m0/s1
• InChIKey: QTGYMFHSEPDEQO-QFIPXVFZSA-N
• SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=C(C=C(C(=C5)C)F)N=C4C3=C2)CN)O

7-Aminomethyl-10-methyl-11-fluoro camptothecin (Cat No.: I045403) is a synthetic analog of camptothecin, engineered to enhance topoisomerase I inhibition and improve anticancer activity. The fluorine substitution and aminomethyl modification increase its lipophilicity, stability, and cell permeability, making it more potent than traditional camptothecin derivatives. It induces DNA damage and apoptosis in rapidly dividing tumor cells. This compound is of particular interest in preclinical oncology research for its potential application in solid tumors and drug-resistant cancer models.

Reference

[1]. Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392.
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