6PGD-IN-S3

• CAT Number: I021009
• CAS Number: 5539-66-2
• Molecular Formula: C15H10O4
• Molecular Weight: 254.24
• Purity: 98%
• Synonyms: 6PGD-IN-S3; 6PGD Inhibitor S3; S3; Danthron methyl derivative
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Sealed in dry,Room Temperature
• IUPAC Name: 1-hydroxy-8-methoxyanthracene-9,10-dione
• InChI: InChI=1S/C15H10O4/c1-19-11-7-3-5-9-13(11)15(18)12-8(14(9)17)4-2-6-10(12)16/h2-7,16H,1H3
• InChIKey: QWZMLZHLNDNLAD-UHFFFAOYSA-N
• SMILES: COC1=CC=CC2=C1C(=O)C3=C(C2=O)C=CC=C3O

1-Hydroxy-8-methoxyanthracene-9,10-dione (Cat No.: I021009), also known as 6PGD-IN-S3, is a ketone derivative and is mainly used as an intermediate in organic synthesis. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

1: Elf S, Lin R, Xia S, Pan Y, Shan C, Wu S, Lonial S, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, Fan J, Chen J. Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene. 2017 Jan 12;36(2):254-262. doi: 10.1038/onc.2016.196. Epub 2016 Jun 6. PubMed PMID: 27270429; PubMed Central PMCID: PMC5464402.
2: Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. doi: 10.1038/ncb3255. Epub 2015 Oct 19. Review. PubMed PMID: 26479318; PubMed Central PMCID: PMC4628560.