6,7-Dinitroquinoxaline-2,3-dione

• CAT Number: R000094
• CAS Number: 2379-57-9
• Molecular Formula: C8H4N4O6
• Molecular Weight: 252.14
• Purity: ≥95%
• Synonyms: 6,7-Dinitro-2,3-dihydroxyquinoxaline; 6,7-Dinitroquinoxaline-2,3-(1H,4H)-dione; DNQX
• Target: Neuronal Signaling
• Storage: -20°C
• IUPAC Name: 6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione
• InChI: InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
• InChIKey: RWVIMCIPOAXUDG-UHFFFAOYSA-N
• SMILES: C1=C2C(=CC(=C1[N+](=O)[O-])[N+](=O)[O-])NC(=O)C(=O)N2

6,7-Dinitroquinoxaline-2,3-dione (Cat No.:R000094) is a potent and selective antagonist of AMPA and kainate-type ionotropic glutamate receptors. Widely used in neuroscience research, DNQX helps elucidate excitatory neurotransmission mechanisms and the role of glutamate in synaptic plasticity, learning, and neurodegenerative diseases. Its dinitro-substituted quinoxalinedione structure confers high receptor binding affinity and specificity. DNQX is typically supplied as a yellow crystalline solid, sparingly soluble in water but soluble in DMSO or ethanol. It is used in electrophysiological and pharmacological studies to block excitatory postsynaptic potentials mediated by non-NMDA receptors.