6-Gingerol（Cat No.:R056629）is a bioactive compound derived from ginger (Zingiber officinale), known for its anti-inflammatory, antioxidant, and anticancer properties. It is the main phenolic component responsible for ginger’s pungent flavor and health benefits. Research has shown that 6-gingerol can inhibit the growth of various cancer cells, reduce inflammation, and enhance antioxidant defenses. Its mechanism of action involves the modulation of multiple signaling pathways, including those related to apoptosis and cell proliferation. 6-Gingerol’s therapeutic potential makes it a promising candidate for further investigation in cancer prevention and management, as well as in the treatment of inflammatory diseases.
| Catalog Number | R056629 |
| CAS Number | 23513-14-6 |
| Synonyms | (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (S)-(+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; (5S)-[6]-Gingerol; (S)-(+)-[6]Gingerol; (S)-[6]Gingerol; [6]-Gingerol; |
| Molecular Formula | C₁₇H₂₆O₄ |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one |
| InChI | InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1 |
| InChIKey | NLDDIKRKFXEWBK-AWEZNQCLSA-N |
| SMILES | CCCCC[C@@H](CC(=O)CCC1=CC(=C(C=C1)O)OC)O |
| Reference | </br>1:Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach. Joshi D, Srivastav SK, Belemkar S, Dixit VA.Biomed Pharmacother. 2017 May 8;91:645-655. doi: 10.1016/j.biopha.2017.04.108. [Epub ahead of print] PMID: 28494418 </br>2:6-Gingerol improves testicular function in mice model of chronic ulcerative colitis. Farombi EO, Adedara IA, Ajayi BO, Idowu TE, Eriomala OO, Akinbote FO.Hum Exp Toxicol. 2017 Jan 1:960327117703689. doi: 10.1177/0960327117703689. [Epub ahead of print] PMID: 28421826 </br>3:Effect of 6-gingerol on physicochemical properties of grass carp (Ctenopharyngodon idellus) surimi fortified with perilla oil during refrigerated storage. Mi H, Zhao B, Wang C, Yi S, Xu Y, Li J.J Sci Food Agric. 2017 Apr 4. doi: 10.1002/jsfa.8350. [Epub ahead of print] PMID: 28374423 </br>4:Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats. Abolaji AO, Ojo M, Afolabi TT, Arowoogun MD, Nwawolor D, Farombi EO.Chem Biol Interact. 2017 May 25;270:15-23. doi: 10.1016/j.cbi.2017.03.017. Epub 2017 Mar 31. PMID: 28373059 </br>5:A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy. Konmun J, Danwilai K, Ngamphaiboon N, Sripanidkulchai B, Sookprasert A, Subongkot S.Med Oncol. 2017 Apr;34(4):69. doi: 10.1007/s12032-017-0931-4. Epub 2017 Mar 27. PMID: 28349496 </br>6:[10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Bernard MM, McConnery JR, Hoskin DW.Exp Mol Pathol. 2017 Apr;102(2):370-376. doi: 10.1016/j.yexmp.2017.03.006. Epub 2017 Mar 16. PMID: 28315687 </br>7:Assessment of anti-cancerous potential of 6-gingerol (Tongling White Ginger) and its synergy with drugs on human cervical adenocarcinoma cells. Zhang F, Zhang JG, Qu J, Zhang Q, Prasad C, Wei ZJ.Food Chem Toxicol. 2017 Feb 27. pii: S0278-6915(17)30084-4. doi: 10.1016/j.fct.2017.02.038. [Epub ahead of print] PMID: 28249781 </br>8:10-Gingerol, a Phytochemical Derivative from /Tongling White Ginger/, Inhibits Cervical Cancer: Insights into the Molecular Mechanism and Inhibitory Targets. Zhang F, Thakur K, Hu F, Zhang JG, Wei ZJ.J Agric Food Chem. 2017 Mar 15;65(10):2089-2099. doi: 10.1021/acs.jafc.7b00095. Epub 2017 Mar 1. PMID: 28230361 </br>9:6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-κB signalling. Li Y, Xu B, Xu M, Chen D, Xiong Y, Lian M, Sun Y, Tang Z, Wang L, Jiang C, Lin Y.Pharmacol Res. 2017 May;119:137-148. doi: 10.1016/j.phrs.2017.01.026. Epub 2017 Feb 4. PMID: 28167239 </br>10:Effect of 6-gingerol on AMPK- NF-κB axis in high fat diet fed rats. Hashem RM, Rashed LA, Hassanin KM, Hetta MH, Ahmed AO.Biomed Pharmacother. 2017 Apr;88:293-301. doi: 10.1016/j.biopha.2017.01.035. Epub 2017 Jan 21. PMID: 28113081 |
