6-Cyano-7-nitroquinoxaline-2,3-dione

• CAT Number: R000498
• CAS Number: 115066-14-3
• Molecular Formula: C9H4N4O4
• Molecular Weight: 232.21
• Purity: ≥95%
• Synonyms: 1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile; CNQX; 6-Cyano-2,3-dihydroxy-7-nitroquinoxaline
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at RT
• IUPAC Name: 7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
• InChI: InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
• InChIKey: RPXVIAFEQBNEAX-UHFFFAOYSA-N
• SMILES: C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N

6-Cyano-7-nitroquinoxaline-2,3-dione(CAT: R000498) is a potent quinoxalinedione derivative widely recognized as an antagonist of ionotropic glutamate receptors, particularly AMPA and kainate subtypes. Its electron-withdrawing cyano and nitro substituents at the 6- and 7-positions enhance binding affinity and selectivity toward excitatory neurotransmitter receptor sites, making it a valuable pharmacological tool in neuroscience research. This compound is commonly used to investigate mechanisms of excitotoxicity, neurodegeneration, and synaptic transmission. With a rigid heteroaromatic framework and excellent receptor interaction profile, it supports studies in epilepsy, ischemia, and neuroprotective drug development.