6-Chloropurine

• CAT Number: R001020
• CAS Number: 87-42-3
• Molecular Formula: C5H3ClN4
• Molecular Weight: 154.56
• Purity: ≥95%
• Synonyms: 6-Chloro-9H-purine; NSC 744
• Storage: -20°C
• IUPAC Name: 6-chloro-7H-purine
• InChI: InChI=1S/C5H3ClN4/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H,7,8,9,10)
• InChIKey: ZKBQDFAWXLTYKS-UHFFFAOYSA-N
• SMILES: C1=NC2=C(N1)C(=NC=N2)Cl

6-Chloropurine(CAT: R001020) is a halogenated purine derivative featuring a chlorine atom at the 6-position of the purine ring. It serves as a key intermediate in the synthesis of nucleoside analogs, antiviral agents, and anticancer compounds. The chlorine substituent enables selective nucleophilic substitution at the 6-position, allowing for the introduction of various amino, alkoxy, or heterocyclic groups. 6-Chloropurine is also used in nucleic acid research, prodrug design, and the preparation of modified DNA/RNA bases. Its structural similarity to natural purines supports its utility in medicinal chemistry, particularly in structure–activity relationship (SAR) and enzyme interaction studies.