6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one

• CAT Number: R026560
• CAS Number: 1016636-76-2
• Molecular Formula: C13H13BrClN3O
• Molecular Weight: 342.62
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one
• InChI: InChI=1S/C13H13BrClN3O/c1-7-9-6-16-13(15)17-11(9)18(12(19)10(7)14)8-4-2-3-5-8/h6,8H,2-5H2,1H3
• InChIKey: HJQCAEDIUJXGCQ-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N(C2=NC(=NC=C12)Cl)C3CCCC3)Br

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one(CAT: R026560) is a heterocyclic compound featuring a fused pyrido-pyrimidine core with halogen and cyclopentyl substitutions. This structure offers significant interest in medicinal chemistry due to its potential as a scaffold for kinase inhibitors, particularly in oncology and inflammation research. The bromine and chlorine atoms provide functional handles for further derivatization via cross-coupling reactions, facilitating structure–activity relationship (SAR) exploration. The cyclopentyl and methyl groups contribute to hydrophobic interactions, enhancing binding affinity and pharmacokinetic properties. This compound serves as a valuable intermediate in the synthesis of targeted small-molecule therapeutics, especially those aimed at ATP-competitive kinase binding sites.