(5R-cis)-Toluene-4-sulfonic Acid 5-(2,4-Difluorophenyl)-5-[1,2,4]triazol-1-ylmethyltetrahydrofuran-3

• CAT Number: R011770
• CAS Number: 149809-43-8
• Molecular Formula: C₂₁H₂₁F₂N₃O₄S
• Molecular Weight: 449.47
• Purity: ≥95%
• Synonyms: 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol; ?
• Storage: Store at -20°C
• IUPAC Name: [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methyl 4-methylbenzenesulfonate
• InChI: InChI=1S/C21H21F2N3O4S/c1-15-2-5-18(6-3-15)31(27,28)30-11-16-9-21(29-10-16,12-26-14-24-13-25-26)19-7-4-17(22)8-20(19)23/h2-8,13-14,16H,9-12H2,1H3/t16-,21-/m0/s1
• InChIKey: DFWVLCJRFGIRAK-KKSFZXQISA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OC[C@H]2C[C@](OC2)(CN3C=NC=N3)C4=C(C=C(C=C4)F)F

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-[1,2,4]triazol-1-ylmethyltetrahydrofuran-3-yl ester（Cat No.:R011770）is a complex chiral intermediate used primarily in the synthesis of pharmaceutical compounds, particularly antifungal agents like triazole derivatives. It features a tetrahydrofuran ring with defined stereochemistry, a difluorophenyl group enhancing bioactivity, and a triazole moiety known for its stability and binding affinity. The tosyl (toluene sulfonic acid) group improves solubility and facilitates downstream reactions. This compound plays a critical role in producing azole-based drugs. It requires careful handling under controlled conditions due to potential reactivity and sensitivity to moisture or light.