5,7-Dichlorokynurenic acid

• CAT Number: M111623
• CAS Number: 131123-76-7
• Molecular Formula: C10H5Cl2NO3
• Molecular Weight: 258.06
• Purity: ≥95%
• Synonyms: 5,7-dichloro-4-oxo-1H-quinoline-2-carboxylic acid
• InChI: InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
• InChIKey: BGKFPRIGXAVYNX-UHFFFAOYSA-N
• SMILES: C1=C(C=C(C2=C1NC(=CC2=O)C(=O)O)Cl)Cl

5,7-Dichlorokynurenic acid（Cat No.:M111623）is a synthetic derivative of kynurenic acid and acts as a potent, selective antagonist of the glycine co-agonist site on the NMDA (N-methyl-D-aspartate) receptor. By inhibiting NMDA receptor activation, it plays a critical role in modulating excitatory neurotransmission and protecting against excitotoxicity. This compound is widely used in neuroscience research to study glutamatergic signaling, synaptic plasticity, and neurodegenerative disorders such as Alzheimer’s disease and epilepsy. Its ability to selectively block NMDA receptor activity makes it a valuable tool for investigating neuroprotection and potential therapeutic targets in central nervous system disorders.