5(S),15(S)-<wbr></wbr>DiHETE is synthesized by 15-<wbr></wbr>LO from 5(S)-<wbr></wbr>HETE. 5(S),15(S)-DiHETE potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB<sub>4</sub>. 5(S),15(S)-<wbr></wbr>DiHETE is chemotactic for eosinophils with an ED<sub>50</sub> value of 0.3 µM.
| Catalog Number | R015770 |
| CAS Number | 82200-87-1 |
| Synonyms | 5S,15S-dihydroxy-6E,8Z,10Z,13E-eicosatetraenoic acid |
| Molecular Formula | C20H32O4 |
| Purity | 95% |
| Storage | -20°C |
| IUPAC Name | (5S,6E,8Z,11Z,13E,15S)-5,15-dihydroxyicosa-6,8,11,13-tetraenoic acid |
| InChI | InChI=1S/C20H32O4/c1-2-3-9-13-18(21)14-10-7-5-4-6-8-11-15-19(22)16-12-17-20(23)24/h5-8,10-11,14-15,18-19,21-22H,2-4,9,12-13,16-17H2,1H3,(H,23,24)/b7-5-,8-6-,14-10+,15-11+/t18-,19+/m0/s1 |
| InChIKey | UXGXCGPWGSUMNI-BVHTXILBSA-N |
| SMILES | CCCCCC(C=CC=CCC=CC=CC(CCCC(=O)O)O)O |
| Reference | 1.Green, F.A. Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism. Lipids 25, 618-623 (1990). |
