For research use only. Not for therapeutic Use.
5-Ph-IAA-AM（Cat No.:I045220）is a cell-permeable, acetoxymethyl ester–protected derivative of 5-phenyl-indole-3-acetic acid (5-Ph-IAA), designed for use in auxin-inducible degron (AID) systems. The AM ester enhances membrane permeability, allowing efficient intracellular delivery, where it is hydrolyzed by cellular esterases to release active 5-Ph-IAA. This molecule binds engineered plant-derived TIR1 F-box proteins, promoting targeted ubiquitination and proteasomal degradation of degron-tagged proteins. 5-Ph-IAA-AM is a valuable chemical biology tool for conditional, rapid, and reversible protein depletion in live cells, enabling precise control of protein function in mechanistic and functional studies.
| CAS Number | 2990123-10-7 |
| Synonyms | acetyloxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate |
| Molecular Formula | C19H17NO4 |
| Purity | ≥95% |
| IUPAC Name | acetyloxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate |
| InChI | InChI=1S/C19H17NO4/c1-13(21)23-12-24-19(22)10-16-11-20-18-8-7-15(9-17(16)18)14-5-3-2-4-6-14/h2-9,11,20H,10,12H2,1H3 |
| InChIKey | FGVMSTLYCNILJO-UHFFFAOYSA-N |
| SMILES | CC(=O)OCOC(=O)CC1=CNC2=C1C=C(C=C2)C3=CC=CC=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
