5'-O-TBDMS-Bz-dA

• CAT Number: I044608
• CAS Number: 51549-39-4
• Molecular Formula: C23H31N5O4Si
• Molecular Weight: 469.61
• Purity: ≥95%
• Synonyms: N-[9-[(2R,4S,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxyoxolan-2-yl]purin-6-yl]benzamide
• InChI: InChI=1S/C23H31N5O4Si/c1-23(2,3)33(4,5)31-12-17-16(29)11-18(32-17)28-14-26-19-20(24-13-25-21(19)28)27-22(30)15-9-7-6-8-10-15/h6-10,13-14,16-18,29H,11-12H2,1-5H3,(H,24,25,27,30)/t16-,17+,18+/m0/s1
• InChIKey: BJZZQJFYKQPUGO-RCCFBDPRSA-N
• SMILES: CC(C)(C)[Si](C)(C)OC[C@@H]1[C@H](C[C@@H](O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)O

5′-O-TBDMS-Bz-dA（Cat No.:I044608）is a protected deoxyribonucleoside phosphoramidite based on deoxyadenosine (dA), featuring a 5′-O-tert-butyldimethylsilyl (TBDMS) group protecting the 5′-hydroxyl and a benzoyl (Bz) group on the exocyclic amino group. The TBDMS group provides strong, selective protection under harsh synthesis conditions and can be removed using fluoride-based reagents. The Bz group ensures stability and minimizes side reactions during chain elongation. 5′-O-TBDMS-Bz-dA is ideal for complex oligonucleotide synthesis, including modified or chimeric sequences used in therapeutic, diagnostic, and structural biology applications requiring high fidelity and chemical resilience.