For research use only. Not for therapeutic Use.
5′-O-DMT-rU（Cat No.:I044601）is a ribonucleoside phosphoramidite featuring ribouridine (rU) with a 5′-O-dimethoxytrityl (DMT) protecting group. This modification safeguards the 5′-hydroxyl during solid-phase RNA synthesis, ensuring accurate sequential nucleotide addition. As uridine is a key pyrimidine in RNA, 5′-O-DMT-rU enables precise incorporation of uridine residues into oligonucleotides. Its high chemical stability and compatibility with standard RNA synthesis protocols make it valuable for producing custom RNA sequences used in research on gene expression, RNA structure, and therapeutic development. This reagent is essential for constructing biologically active or structurally modified RNA molecules.
| CAS Number | 81246-79-9 |
| Synonyms | 1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]pyrimidine-2,4-dione |
| Molecular Formula | C30H30N2O8 |
| Purity | ≥95% |
| IUPAC Name | 1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]pyrimidine-2,4-dione |
| InChI | InChI=1S/C30H30N2O8/c1-37-22-12-8-20(9-13-22)30(19-6-4-3-5-7-19,21-10-14-23(38-2)15-11-21)39-18-24-26(34)27(35)28(40-24)32-17-16-25(33)31-29(32)36/h3-17,24,26-28,34-35H,18H2,1-2H3,(H,31,33,36)/t24-,26-,27-,28-/m1/s1 |
| InChIKey | PCFSNQYXXACUHM-YULOIDQLSA-N |
| SMILES | COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=CC(=O)NC5=O)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
