For research use only. Not for therapeutic Use.
5′-O-DMT-rI（Cat No.:M027122）is a ribonucleoside phosphoramidite based on riboinosine (rI), protected with a 5′-O-dimethoxytrityl (DMT) group to block the 5′-hydroxyl during RNA chain assembly. Inosine plays a critical role in RNA editing and wobble base pairing, making 5′-O-DMT-rI essential for synthesizing RNA molecules with enhanced coding flexibility and regulatory functions. This reagent ensures high coupling efficiency and stability under solid-phase synthesis conditions. It supports the creation of RNA constructs for studies in translation, tRNA modification, and synthetic biology, especially where inosine incorporation mimics or investigates natural RNA editing processes.
| CAS Number | 119898-59-8 |
| Synonyms | 9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-1H-purin-6-one |
| Molecular Formula | C31H30N4O7 |
| Purity | ≥95% |
| IUPAC Name | 9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-1H-purin-6-one |
| InChI | InChI=1S/C31H30N4O7/c1-39-22-12-8-20(9-13-22)31(19-6-4-3-5-7-19,21-10-14-23(40-2)15-11-21)41-16-24-26(36)27(37)30(42-24)35-18-34-25-28(35)32-17-33-29(25)38/h3-15,17-18,24,26-27,30,36-37H,16H2,1-2H3,(H,32,33,38)/t24-,26-,27-,30-/m1/s1 |
| InChIKey | PQXVLEMIGAJLIN-BQOYKFDPSA-N |
| SMILES | COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=NC6=C5N=CNC6=O)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
