5'-O-DMT-N6-Me-2'-dA

• CAT Number: R056320
• CAS Number: 98056-69-0
• Molecular Formula: C32H33N5O5
• Molecular Weight: 567.63
• Purity: ≥95%
• Synonyms: (2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-[6-(methylamino)purin-9-yl]oxolan-3-ol
• InChI: InChI=1S/C32H33N5O5/c1-33-30-29-31(35-19-34-30)37(20-36-29)28-17-26(38)27(42-28)18-41-32(21-7-5-4-6-8-21,22-9-13-24(39-2)14-10-22)23-11-15-25(40-3)16-12-23/h4-16,19-20,26-28,38H,17-18H2,1-3H3,(H,33,34,35)/t26-,27+,28+/m0/s1
• InChIKey: OKZZBPBWGABLJR-UPRLRBBYSA-N
• SMILES: CNC1=C2C(=NC=N1)N(C=N2)[C@H]3C[C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

5′-O-DMT-N6-Me-2′-dA（Cat No.:R056320）is a modified deoxyribonucleoside phosphoramidite featuring 2′-deoxyadenosine (2′-dA) with a methyl group at the N6 position and a 5′-O-dimethoxytrityl (DMT) group protecting the 5′-hydroxyl. The N6-methylation introduces an epigenetic modification commonly found in regulatory DNA regions, allowing researchers to investigate methylation effects on gene expression, DNA-protein interactions, and epigenetic signaling. The DMT protection ensures compatibility with automated DNA synthesis, supporting high coupling efficiency and clean deprotection. This reagent is ideal for constructing methylated oligonucleotides used in studies of epigenetics, gene regulation, and nucleic acid-based assay development.