For research use only. Not for therapeutic Use.
5′-O-DMT-N6-ibu-dA（Cat No.:I044603）is a deoxyribonucleoside phosphoramidite based on deoxyadenosine (dA), featuring a 5′-O-dimethoxytrityl (DMT) group for 5′-hydroxyl protection and an N6-isobutyryl (ibu) group on the exocyclic amino group. The isobutyryl protection enhances stability and minimizes side reactions during solid-phase DNA synthesis. This reagent offers efficient coupling and clean deprotection, making it suitable for synthesizing high-purity oligonucleotides. 5′-O-DMT-N6-ibu-dA is commonly used in constructing DNA strands for applications in molecular biology, genomics, and therapeutic research, especially where precise sequence fidelity and chemical robustness are essential for downstream performance.
| CAS Number | 190834-10-7 |
| Synonyms | N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]purin-6-yl]-2-methylpropanamide |
| Molecular Formula | C35H37N5O6 |
| Purity | ≥95% |
| IUPAC Name | N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]purin-6-yl]-2-methylpropanamide |
| InChI | InChI=1S/C35H37N5O6/c1-22(2)34(42)39-32-31-33(37-20-36-32)40(21-38-31)30-18-28(41)29(46-30)19-45-35(23-8-6-5-7-9-23,24-10-14-26(43-3)15-11-24)25-12-16-27(44-4)17-13-25/h5-17,20-22,28-30,41H,18-19H2,1-4H3,(H,36,37,39,42)/t28-,29+,30+/m0/s1 |
| InChIKey | LVBIHUHWVGOJFS-FRXPANAUSA-N |
| SMILES | CC(C)C(=O)NC1=C2C(=NC=N1)N(C=N2)[C@H]3C[C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
