5'-O-DMT-N2-DMF-dG

• CAT Number: I044602
• CAS Number: 40094-22-2
• Molecular Formula: C34H36N6O6
• Molecular Weight: 624.69
• Purity: ≥95%
• Synonyms: N’-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide
• IUPAC Name: N'-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide
• InChI: InChI=1S/C34H36N6O6/c1-39(2)20-36-33-37-31-30(32(42)38-33)35-21-40(31)29-18-27(41)28(46-29)19-45-34(22-8-6-5-7-9-22,23-10-14-25(43-3)15-11-23)24-12-16-26(44-4)17-13-24/h5-17,20-21,27-29,41H,18-19H2,1-4H3,(H,37,38,42)/t27-,28+,29+/m0/s1
• InChIKey: YTRIMRXIMVGPAL-ZGIBFIJWSA-N
• SMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2[C@H]3C[C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

5′-O-DMT-N2-DMF-dG（Cat No.:I044602）is a deoxyribonucleoside phosphoramidite derived from deoxyguanosine (dG), featuring a 5′-O-dimethoxytrityl (DMT) group for 5′-hydroxyl protection and an N2-dimethylformamidine (DMF) group safeguarding the exocyclic amino group. This dual protection ensures high stability and coupling efficiency during automated DNA synthesis. The DMF group minimizes side reactions and maintains guanine’s hydrogen-bonding potential post-deprotection. 5′-O-DMT-N2-DMF-dG is crucial for synthesizing DNA oligonucleotides with accurate sequence fidelity, supporting applications in molecular diagnostics, gene editing, and nucleic acid-based therapeutics. Its chemical design enhances performance in both standard and modified DNA synthesis protocols.