For research use only. Not for therapeutic Use.
5-Iminodaunorubicin（Cat No.:I044587）is a synthetic derivative of daunorubicin, an anthracycline chemotherapeutic agent known for its DNA-intercalating and topoisomerase II-inhibiting properties. The introduction of an imino group at the 5-position modifies its physicochemical and biological behavior, potentially enhancing anticancer efficacy and altering resistance profiles. 5-Iminodaunorubicin retains strong cytotoxic activity against a variety of cancer cell lines, including hematologic malignancies and solid tumors. It is primarily used in preclinical research to explore novel mechanisms of action, evaluate drug resistance, and develop improved anthracycline-based therapies with potentially reduced cardiotoxic effects.
| CAS Number | 72983-78-9 |
| Synonyms | (8S,10S)-8-acetyl-10-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-12-imino-1-methoxy-9,10-dihydro-7H-tetracen-5-one |
| Molecular Formula | C27H30N2O9 |
| Purity | ≥95% |
| IUPAC Name | (8S,10S)-8-acetyl-10-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-12-imino-1-methoxy-9,10-dihydro-7H-tetracen-5-one |
| InChI | InChI=1S/C27H30N2O9/c1-10-23(31)14(28)7-17(37-10)38-16-9-27(35,11(2)30)8-13-19(16)26(34)20-21(25(13)33)24(32)12-5-4-6-15(36-3)18(12)22(20)29/h4-6,10,14,16-17,23,29,31,33-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,23+,27-/m0/s1 |
| InChIKey | BLLIIPIJZPKUEG-HPTNQIKVSA-N |
| SMILES | C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=N)C(=CC=C5)OC)O)(C(=O)C)O)N)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
