5-Iminodaunorubicin hydrochloride

• CAT Number: I044586
• CAS Number: 67324-99-6
• Molecular Formula: C27H31ClN2O9
• Molecular Weight: 563.00
• Purity: ≥95%
• Synonyms: (8S,10S)-8-acetyl-10-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-12-imino-1-methoxy-9,10-dihydro-7H-tetracen-5-one;hydrochloride
• InChI: InChI=1S/C27H30N2O9.ClH/c1-10-23(31)14(28)7-17(37-10)38-16-9-27(35,11(2)30)8-13-19(16)26(34)20-21(25(13)33)24(32)12-5-4-6-15(36-3)18(12)22(20)29;/h4-6,10,14,16-17,23,29,31,33-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,23+,27-;/m0./s1
• InChIKey: KVTVLWOKIDKIQL-KOFUDPRISA-N
• SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=N)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl

5-Iminodaunorubicin hydrochloride（Cat No.:I044586）is a synthetic anthracycline derivative structurally related to daunorubicin, designed to enhance anticancer activity while potentially reducing cardiotoxicity. It functions by intercalating DNA and inhibiting topoisomerase II, thereby disrupting DNA replication and transcription in rapidly dividing cancer cells. This compound exhibits potent cytotoxic effects against various tumor cell lines, including leukemias and solid tumors. The modification at the 5-position introduces an imino group, which may influence cellular uptake or resistance profiles. 5-Iminodaunorubicin hydrochloride is valuable for anticancer drug development and mechanistic studies in oncology research.